Saframycin A ( NSC 325663 )

Catalog No. M15514 CAS No. 66082-27-7

A heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro.

Purity : >98% (HPLC)

COA

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Biological Information

Product Name

Saframycin A
Note

Research use only, not for human use.
Brief Description

A heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro.
Description

A heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro; shows potent antiproliferative effects in leukemia- and tumor-derived cells; induces nuclear translocation of GAPDH in cancer cells.
Synonyms

NSC 325663
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA/RNA Synthesis
Research Area

——
Indication

——

Chemical Information

CAS Number

66082-27-7
Formula Weight

562.58
Molecular Formula

C29H30N4O8
Purity

>98% (HPLC)
Solubility

——
SMILES

COC1=C(C(C2=C(C1=O)[C@@H](N3[C@H]([C@H]4N([C@@H]([C@@H]3C#N)CC5=C4C(C(OC)=C(C5=O)C)=O)C)C2)CNC(C(C)=O)=O)=O)C
Chemical Name

N-[[(6S,7R,9R,14aS,15R)-7-Cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxopropanamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Xing C, et al. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5862-6.
2. Ishiguro K, et al. Biochemistry. 1978 Jun 27;17(13):2545-50.
3. Spencer JR, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4884-8.

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